Project Code
MRCNMH25Br Hodge
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
CASK is a protein found at synapses between neurons in the brain. Human mutations cause brain and behavioural problems including severe epilepsy, sleep, movement and learning disabilities. You will be trained to generate fly and cell-based models of CASK disease characterising them using cutting-edge molecular genetics, behaviour, electrophysiology, imaging, computational modelling and pharmacology. You will work with our clinical team and patient groups generating human CASK molecular and clinical data identifying new mutations and symptoms which you will then study using your fly and cell models allowing you to test novel genetic and drug treatments, prior to follow-on clinical trials.
Lead Supervisor
Professor James Hodge
Lead Supervisor Email
james.hodge@bristol.ac.uk
University Affiliation
Bristol