Computing and translating mechanisms of neural network dysfunction associated with psychiatric risk

Project Code

MRCNMH25Br Jones 

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

Psychotic disorders are common, chronic and poorly-treated; his cannot change until we understand their biological basis. This PhD project will integrate mouse electrophysiology and computational generative modelling, set in the context of patient-public involvement and engagement (PPIE) with children and young people, to define the neural network mechanisms contributing to psychiatric risk in people living with psychosis-associated genetic mutations. The project will be embedded in a vibrant, innovative, supportive and collaborative team spanning Bristol, Exeter and Cardiff universities and encompassing genomic, cellular, circuit, cognitive and clinical analyses in patients and mice.

Lead Supervisor

Professor Matt Jones

Lead Supervisor Email

matt.jones@bristol.ac.uk

University Affiliation

Bristol