Decoding HIV-1: Genetic Influences on Virus Replication and Transmission

Project Code

MRCIIAR25Br Mann 

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Project Summary Download

Summary

This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (C-HIV) as the most prevalent strain. Understanding why C-HIV has become predominant in certain regions of the world is crucial for deciphering its transmission dynamics and impact. Through advanced genetic analysis coupled with state-of-the-art experimental models, we aim to uncover the genetic determinants driving C-HIV’s success. This research aims to deepen our understanding of HIV-1 evolution and develop innovative strategies to combat the virus and mitigate its impact.

Lead Supervisor

Dr Jamie Mann

Lead Supervisor Email

jamie.mann@bristol.ac.uk

University Affiliation

Bristol