Project Code
MRCIIAR25Br Laabei
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Antimicrobial resistance (AMR) has been described as the silent pandemic, fuelled in part by insufficient antibiotic development. We have identified novel small molecules that target a crucial bacterial component called lipoteichoic acid. Precise understanding of how antibiotics kill bacteria is critical to the safe and effective use of antimicrobials in therapy. By combining molecular microbiology, proteomics, and medicinal and analytical chemistry, this proposal aims to unravel the mechanism of action of a novel class of antibiotic, the oxadiazole based small molecule which we have shown potently inhibits multi-drug resistant bacterial pathogens, most notably methicillin-resistant Staphylococcus aureus.
Lead Supervisor
Dr Maisem Laabei
Lead Supervisor Email
maisem.laabei@bristol.ac.uk
University Affiliation
Bristol