Project Code
MRCIIAR25Br Avison
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repai
Project Summary Download
Summary
Reducing antibiotic resistance (ABR) among urosepsis pathogens – derived from urinary tract infection (UTI) via pyelonephritis – is central to the UKs ABR-reduction strategy. This PhD is based within an inter-disciplinary consortium aiming to reduce trimethoprim use for UTI by promoting switching to an alternative first-line antibiotic. This may reduce resistance to second-line UTI/pyelonephritis and urosepsis therapies among UTI pathogens, reducing hospital admissions and saving lives. You will use genomic epidemiology and functional genomics to identify and explain links between resistance to several alternative first-line, second-line and urosepsis therapies with findings helping the consortium to inform UK antibiotic prescribing policy.
Lead Supervisor
Professor Matthew Avison
Lead Supervisor Email
bimba@bristol.ac.uk
University Affiliation
Bristol