Project Code
MRCIIAR25Br Oliveria
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Bacterial antibiotic resistance is a global public health crisis. New antibiotics for resistant organisms are urgently needed, but attempts to identify new molecular targets in bacteria have been largely unsuccessful. One alternative approach is to identify new routes to disrupting the function of known, validated targets. This project applies state of the art computational methodologies, developed in our group, to investigate communication networks in the multisubunit protein machine and antibiotic target DNA gyrase. We will explore how gyrase activity is coordinated and affected by mutations, and use this information to identify new binding sites for small molecules/potential antibacterial candidates.
Lead Supervisor
Dr Sofia Oliveira
Lead Supervisor Email
sofia.oliveira@bristol.ac.uk
University Affiliation
Bristol