Project Code
MRCIIAR25Ex Scotton
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Lung fibrosis is a devastating disease which causes 1% of all UK deaths. On average, patients only survive 2-3 years after diagnosis. Ageing is a big risk factor; patients often have unusually short telomeres (the protective shields at the ends of our chromosomes). This shortening appears to be linked with reduced sex hormone levels in the blood. We will investigate if boosting hormone levels might improve telomere length and reduce disease burden – using data from cutting-edge lab experiments with lung cells, combined with analyses of patient genetics.
Lead Supervisor
Professor Chris Scotton
Lead Supervisor Email
c.j.scotton@exeter.ac.uk
University Affiliation
Exeter