Neuroimaging brain reward systems to stratify patients across the psychosis spectrum

Project Code

MRCNMH25Ba Lancaster

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

Severe mental illness with psychosis symptoms (e.g. bipolar disorder, schizophrenia) are reliably linked to alterations in brain reward circuitry. Neuroimaging techniques can predict diagnosis of individuals with/without psychosis by assessing neurophysiological alterations within key nodes of brain reward circuitry. However, little is known about the specificity, clinical correlates, or neurobiology of this biomarker. The candidate will join an established GW4-aligned mental health hub (Brain & Genomics UKRI Mental Health Platform) to assess how reward circuity is different in individuals with different diagnosis, medications, symptoms and genetic risk. This project will refine diagnosis and treatment strategies for individuals experiencing psychosis.

Lead Supervisor

Dr Tom Lancaster

Lead Supervisor Email

tml45@bath.ac.uk

University Affiliation

Bath