Project Code
MRCIIAR25Ex Sanders
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Antimicrobial resistance (AMR) is rising to dangerously high levels causing a global health crisis. To develop strategies to combat AMR, we need to know how AMR genes are spreading. Plasmids as ubiquitous mobile genetic elements are key players of AMR spread. Antibiotics make carry AMR plasmids beneficial to their bacterial hosts and therefore drive plasmid prevalence and evolution. This project will investigate the evolution of highly transmissible AMR plasmids that can spread resistance within and between microbiomes. This will be done by targeted experiments and investigations of complex microbiomes using plasmid genomics and network analysis.
Lead Supervisor
Dr Dirk Sanders
Lead Supervisor Email
d.sanders@exeter.ac.uk
University Affiliation
Exeter