Project Code MRCNMH25Ba Button Research Theme Neuroscience and Mental Health Project Summary Download Summary In public discourse, social media is often claimed to be bad for young people’s mental health. This simple view is not supported by science, where the…
Brain stimulation and neurophysiological investigations of central nervous system changes in pathological pain, and their augmentation by treatment.
Project Code MRCNMH25Ba Bultitude Research Theme Neuroscience and Mental Health Project Summary Download Summary Chronic pain can involve changes throughout the central nervous system (CNS). Some treatments aim to alter CNS function, with limited results. This could be because research…
Synthetic heroin: understanding the dangers of nitazene drugs
Project Code MRCNMH25Ba Bailey Research Theme Neuroscience and Mental Health Project Summary Download Summary “Drug-related deaths are now at the highest ever recorded in the UK, the majority involving opioid drugs. Recently, a new class of synthetic opioids known as…
Developing phage therapy solutions for Staphylococcus aureus
Project Code MRCIIAR25Ex Westra Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary “The spread of antimicrobial resistance (AMR) is a slow-moving pandemic, identified by the WHO as a top-10 threat facing humanity. Staphylococcus aureus is an…
Genetic predisposition to accelerated ageing: targeting telomeres using sex hormone supplementation in chronic lung disease
Project Code MRCIIAR25Ex Scotton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Lung fibrosis is a devastating disease which causes 1% of all UK deaths. On average, patients only survive 2-3 years after diagnosis. Ageing is…
The controlled spreading of Wnt receptors determines signalling in the tumour microenvironment
Project Code MRCIIAR25Ex Schlopp Research Theme Cross-CuttingInfection, Immunity, Antimicrobial Resistance and RepairNeuroscience and Mental HealthPopulation Health Sciences Project Summary Download Summary Cells communicate by sending signals that cause receiving cells to change their behaviour. In response to such a signal,…
Plasmids as AMR vectors
Project Code MRCIIAR25Ex Sanders Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) is rising to dangerously high levels causing a global health crisis. To develop strategies to combat AMR, we need to know…
Will climate change worsen the problem of antibiotic resistance?
Project Code MRCIIAR25Ex Padfield Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding of the mechanisms causing…
Investigating the impact of epigenetic modifiers, a new treatment for cancer, on fungal pathogens
Project Code MRCIIAR25Ex Neutzmann Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal pathogens threaten our health and kill over a million patients worldwide. In this project, we will deploy cutting-edge epigenetics research and medical microbiology…
Uncovering new genetic mechanisms of beta-cell autoimmunity to better understand type 1 diabetes
Project Code MRCIIAR25Ex Johnson Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project uses a unique collection of samples from people with diabetes to address a fundamental question: What are the genetic mechanisms underpinning beta-cell…