Project Code MRCIIAR25Br Shytaj Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with limited treatment options. Our…
Investigating the mechanisms underlying Professional killer cell dysfunction in dengue
Project Code MRCIIAR25Br Rivino Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Dengue is a mosquito-borne virus infection now affecting half of the world’s population. There is no cure or broadly protective vaccine for dengue. During…
Exploring Communication Networks in Proteins to Enable Antibiotic Discovery
Project Code MRCIIAR25Br Oliveria Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacterial antibiotic resistance is a global public health crisis. New antibiotics for resistant organisms are urgently needed, but attempts to identify new molecular targets…
Decoding HIV-1: Genetic Influences on Virus Replication and Transmission
Project Code MRCIIAR25Br Mann Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (C-HIV) as the most…
Developing new weapons to fight drug-resistant superbugs – targeting lipoteichoic acid biosynthesis
Project Code MRCIIAR25Br Laabei Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) has been described as the silent pandemic, fuelled in part by insufficient antibiotic development. We have identified novel small molecules that…
Emerging co-resistance to first and second line antibiotics in urinary pathogens and implications for the control of urosepsis.
Project Code MRCIIAR25Br Avison Research Theme Infection, Immunity, Antimicrobial Resistance and Repai Project Summary Download Summary Reducing antibiotic resistance (ABR) among urosepsis pathogens – derived from urinary tract infection (UTI) via pyelonephritis – is central to the UKs ABR-reduction strategy.…
Airborne transmission of pathogens: defining microbial and environmental factors affecting survival in aerosols.
Project Code MRCIIAR25Ba Preston Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Numerous bacteria transmit between hosts via the air, representing a key step in the pathogen lifecycle. However, we know little about the microbial and…
Tackling Antimicrobial Resistance with Targeted Covalent Macrocycles
Project Code MRCIIAR25Ba Lovell Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Infections with drug-resistant bacteria are major threats to human health. Discovering novel druggable targets for antimicrobial development is a pivotal task to guarantee effective…
Using AI to understand defence and counter-defence systems between bacteria and phage
Project Code MRCIIAR25Ba Iqbal Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacteria have been engaged in a war with the viruses that predate on them (“phage”) for millions of years, both sides developing defence/counter-defence systems.…
Environmental and genetic determinants of transmission by a parasitic nematode
Project Code MRCIIAR25Ba Hunt Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The parasitic nematode Strongyloides infects >600 million people and is transmitted between hosts through a larval stage in the soil. We know little about…