Project Code MRCNMH25Ex Richards Research Theme Neuroscience & Mental Health Project Summary Download Summary During this exciting, fully-funded PhD, you will use machine learning to automatically classify the state of microglia (the brain’s specialised immune cells). This will involve combining…
Mapping Preterm Sleep Microstructure and EEG Biomarkers for Early Neurodevelopmental Risk Assessment
Project Code MRCNMH25Ex Poorun Research Theme Neuroscience & Mental Health Project Summary Download Summary Sleep is crucial for early brain development, yet preterm infants often have disrupted sleep patterns that may impact their long-term outcomes. This project will use advanced…
Development and characterisation of reproducible complex human brain organoids – Bio-engineering and neuronal networks
Project Code MRCNMH25Ex Piers Research Theme Neuroscience & Mental Health Project Summary Download Summary Using induced pluripotent stem cells, we can generate complex multi-cellular 3D human brain tissue models in a dish, termed cerebral organoids. These models provide unique opportunities…
AI-Powered Fatigue Solutions: Transforming Care for Neurological Conditions
Project Code MRCNMH25Ex Mansoubi Research Theme Neuroscience & Mental Health Project Summary Download Summary Fatigue is a major issue for individuals with neurological conditions, often leading to lower quality of life. This project aims to empower these individuals through an…
What is it like to have advanced dementia? Using remote measurement of EEG and physiological markers of sleep, arousal and awareness in people with advanced Alzheimer’s disease
Project Code MRCNMH25Ex Huntley Research Theme Neuroscience & Mental Health Project Summary Download Summary What is it like to have advanced dementia? How do changes in sleep and awareness impact the behaviour and quality of life of people living with…
Understanding motor neuron disease using a powerful combination of model systems
Project Code MRCNMH25Ex Housden Research Theme Neuroscience & Mental Health Project Summary Download Summary The aim of this project is to understand the mechanisms that cause motor neuron disease (MND) so that new treatments can be developed. This is important…
The consequence of mitochondrial import failure in neurogenerative disease
Project Code MRCNMH25Ex Gold Research Theme Neuroscience & Mental Health Project Summary Download Summary Mitochondria provide energy essential for life and are dependent on the delivery of proteins from the cytosol for their biogenesis, maintenance and regeneration. Defects in protein…
Artificial Intelligence-enhanced mobile Behavioural Activation therapy for Dementia and Mild cognitive impairment (AI-BADeM)
Project Code MRCNMH25Ex Fox Research Theme Neuroscience & Mental Health Project Summary Download Summary Dementia affects around 55 million people globally, often leading to depression and unhealthy behaviours like physical inactivity and social isolation. These issues can worsen cognitive decline…
Epigenetic mechanisms in stem cell models of Rett syndrome
Project Code MRCNMH25Ex Flynn Research Theme Neuroscience & Mental Health Project Summary Download Summary Rett syndrome (RTT) is a neurodevelopmental disorder that causes physical and mental disability from early childhood. It is characterised by impaired motor and cognitive function and…
Cell-type-specific epigenetic regulation of gene expression in Motor Neuron Disease
Project Code MRCNMH25Ex Dempster Research Theme Neuroscience & Mental Health Project Summary Download Summary This project aims to uncover new molecular insights into Motor Neuron Disease (MND) using advanced molecular technologies. It involves studying human post-mortem brain tissue and cells…