Project Code MRCNMH26Ex Bhinge Project Type Primarily wet-lab with a strong computational component. Research Theme Neuroscience and Mental Health Project Summary Download Summary ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand…
Capturing the Molecular Basis of Altered Learning in Schizophrenia
Project Code MRCNMH26Ex Clifton Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary In this interdisciplinary PhD project, you will explore how memory is altered in schizophrenia by investigating the neurons activated during learning. Using…
Architects of the Genome: Using genomic technologies to elucidate the role of CTCF in neurodevelopmental disorders
Project Code MRCNMH26Ex Flynn Project Type The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3. Research Theme Neuroscience and Mental Health Project Summary Download Summary Genetic variants in the CTCF gene, which encodes a…
Capturing primitive haematogenesis and microglia function ex vivo using human stem cell-based models
Project Code MRCNMH26Ex Guo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project aims to uncover how early human immune cells, especially microglia (the brain’s immune cells), form during development. Since studying human…
Investigating the role microRNAs play in the pathophysiology of Huntington’s disease and whether they could be targeted therapeutically
Project Code MRCNMH26Ex Lunnon Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene, with age of onset influenced by…
Epigenetic profiling in Parkinson’s disease: novel mechanisms and drug targets
Project Code MRCNMH26Ex Migdalska-Richards Project Type A particular strength of this project is that it combines both wet-lab work (microRNA profiling, cell culturing and transfection) and bioinformatics, allowing the student to acquire a valuable combination of skills that will be…
Molecular signatures of sex differences in the human brain
Project Code MRCNMH26Ex Mill Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Why do males and females show different risks for brain disorders like schizophrenia, depression, autism and Alzheimer’s? This project explores how sex…
Ketamine Use Disorder: Exploring Psychological and Neurological Mechanisms
Project Code MRCNMH26Ex Morgan Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Ketamine use disorder is the fastest growing addiction in the UK, with ~ 300% increase in people seeking treatment over the past…
Can supporting cells of the brain help to treat Alzheimer’s disease?
Project Code MRCNMH26Ex Noble Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Tau tangles accumulate mainly in neurons in Alzheimer’s disease brain. We recently found that blocking inflammatory signals in non-neuronal cells caused a…
Neuronal Clues to Astrocytes: Uncovering Hidden Mechanisms in the Developing Brain
Project Code MRCNMH26Ex Oguro-Ando Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How do neuronal signals drive astrocyte-mediated changes in brain development? This project will investigate the underlying cellular and molecular mechanisms by which…