Project Code MRCPHS25Ba McGrogan Research Theme Population Health Sciences Project Summary Download Summary Did you know that only 5% of medicines licensed in the UK have sufficient evidence about their safety in pregnancy? Women may be advised not to use…
Causal inference tools to study vaccines using real-world data: how can we make better use of negative control outcomes?
Project Code MRCPHS25Ba McDonald Research Theme Population Health Sciences Project Summary Download Summary “Vaccination saves lives! Observational vaccine studies are important to assess real-world effectiveness and safety, but people who receive vaccines differ from those who do not, so confounding…
Parental transmission of substance use: exploring mechanisms and informing intervention
Project Code MRCPHS25Ba Hines Research Theme Population Health Sciences Project Summary Download Summary Reducing substance use is a key goal within public health. Recent work has shown that a strong predictor of adolescent substance use is the substance use of…
An investigation of the factors that influence post-disaster mental health in a Brazilian birth cohort study
Project Code MRCPHS25Ba Halligan Research Theme Population Health Sciences Project Summary Download Summary Exposure to traumatic events like disasters is a major risk factor for poor mental health. However, understanding of the pre-existing factors that contribute to better or worse…
Brain growth mechanisms involving axon volume and myelination linked with autism spectrum disorder.
Project Code MRCNMH25Ba Ward Research Theme Neuroscience and Mental Health Project Summary Download Summary Correct axonal volume and myelination are essential for neuronal function. Little is currently known about mechanisms controlling axon volume and loss of brain myelin occurs in…
What are the biological mechanisms underlying the association between smoking, smoking cessation and mental health: a triangulation approach using machine learning, mendelian randomisation, and g-methods applied to multiple biological cohort studies.
Project Code MRCNMH25Ba Taylor Research Theme Neuroscience and Mental Health Project Summary Download Summary What are the biological mechanisms underlying the association between smoking, smoking cessation, and mental health? A growing body of evidence supports smoking as a causal risk…
Identification of ion channel dysfunction in epilepsy with machine learning
Project Code MRCNMH25Ba Nogaret Research Theme Neuroscience and Mental Health Project Summary Download Summary Ion channel mutations are increasingly recognised as an early prognosis for neurological disease. The identification of dysfunctional ion channels is currently hindered by the lack of…
Targeted protein degradation in CNS disorders
Project Code MRCNMH25Ba Licchesi Research Theme Neuroscience and Mental Health Project Summary Download Summary Targeted protein degradation (TPD) has emerged has a new therapeutic modality for the on-demand removal of disease-causing proteins. TPD employs hetero-bifunctional molecules which can bind a…
Neuroimaging brain reward systems to stratify patients across the psychosis spectrum
Project Code MRCNMH25Ba Lancaster Research Theme Neuroscience and Mental Health Project Summary Download Summary Severe mental illness with psychosis symptoms (e.g. bipolar disorder, schizophrenia) are reliably linked to alterations in brain reward circuitry. Neuroimaging techniques can predict diagnosis of individuals…
Man up? Examining attitudes and experiences around mental health and help-seeking
Project Code MRCNMH25Ba Lambert Research Theme Neuroscience and Mental Health Project Summary Download Summary “Women seek help – men die”. Comparatively lower rates of mental illness among men than women are not explained by better health among men. Men face…