Project Code MRCNMH26Ba Paskell Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Third-sector staff working to prevent or support those affected by community violence are regularly exposed to high-levels of trauma, limited funding, and…
Decoding the Cellular Origin of Barrett’s Metaplasia Using Microlasers and Lab-on-a-Chip Technologies
Project Code MRCIIAR26Ba Caixeiro Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises from chronic acid reflux. It involves the transformation of…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code MRCIIAR26Ba Jones Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens.…
A covalent phage display approach to identify complement-targeted autoimmune therapeutics
Project Code MRCIIAR26Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage…
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives of previous drugs and resistance adapts quickly to the new derivatives, greatly limiting their useful…
Novel digital diagnostics for antimicrobial resistance based on ion-channel communication
Project Code MRCIIAR26Ba Reis Project Type Dry lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacterial infections affect millions of people worldwide. Current methodologies for bacterial identification and antibiotic susceptibility testing (AST) are time consuming…
Understanding β-lactam antibiotic action and resistance with developments in dynamic structural biology
Project Code MRCIIAR26Ba Tooke Project Type This project combines both wet and dry lab elements. The primary focus will be on wet-lab methods (enzyme purification, biochemical characterisation of enzymes, structural biology) but will feature dry lab approaches (biomolecular simulation). Research…
Understanding and supporting psychological trauma related to the experience and treatment of eating disorders
Project Code MRCNMH26Ba Atkinson Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Eating disorders (EDs) can be linked to early trauma (physical and psychological). However the experience of having an ED – and going…
Synthetic heroin: understanding the dangers of nitazene drugs
Project Code MRCNMH26Ba Bailey Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Drug-related deaths are now at the highest ever recorded in the UK, the majority involving opioid drugs. Currently, a new class of…
Multi-method exploration into psychosocial contributors to pain across the lifespan
Project Code MRCNMH26Ba Barry Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Chronic pain is the costliest health problem that exists. Our understanding of the psychological and social processes that explain why some people…