Project Code MRCIIAR25Br Van Der Kamp Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β-lactamases are not well understood,…
Small-Molecule G-Quadruplex (G4) Ligands as Candidate Antibacterials for Resistant Bacteria
Project Code MRCIIAR25Br Spencer Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Increasing resistance makes developing new antibiotics, that kill bacteria by different mechanisms from existing agents, a public health priority. G-quadruplexes (G4s) are specific nucleotide…
Exploring the modulation of Antioxidant Metabolism to target Adult T-Cell Leukaemia Induced by HTLV-1 Infection
Project Code MRCIIAR25Br Shytaj Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with limited treatment options. Our…
Investigating the mechanisms underlying Professional killer cell dysfunction in dengue
Project Code MRCIIAR25Br Rivino Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Dengue is a mosquito-borne virus infection now affecting half of the world’s population. There is no cure or broadly protective vaccine for dengue. During…
Exploring Communication Networks in Proteins to Enable Antibiotic Discovery
Project Code MRCIIAR25Br Oliveria Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacterial antibiotic resistance is a global public health crisis. New antibiotics for resistant organisms are urgently needed, but attempts to identify new molecular targets…
Decoding HIV-1: Genetic Influences on Virus Replication and Transmission
Project Code MRCIIAR25Br Mann Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (C-HIV) as the most…
Developing new weapons to fight drug-resistant superbugs – targeting lipoteichoic acid biosynthesis
Project Code MRCIIAR25Br Laabei Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) has been described as the silent pandemic, fuelled in part by insufficient antibiotic development. We have identified novel small molecules that…
Emerging co-resistance to first and second line antibiotics in urinary pathogens and implications for the control of urosepsis.
Project Code MRCIIAR25Br Avison Research Theme Infection, Immunity, Antimicrobial Resistance and Repai Project Summary Download Summary Reducing antibiotic resistance (ABR) among urosepsis pathogens – derived from urinary tract infection (UTI) via pyelonephritis – is central to the UKs ABR-reduction strategy.…