Project Code MRCNMH25Br Corey Research Theme Neuroscience and Mental Health Project Summary Download Summary Fentanyl is a dangerous synthetic opioid that is responsible for more US overdoses than any other drug, yet much remains to be understood about its pharmacology.…
Cannabinoids in the ticking network of the brainstem satiety centre
Project Code MRCNMH25Br Chrobok Research Theme Cross-CuttingInfection, Immunity, Antimicrobial Resistance and RepairNeuroscience and Mental HealthPopulation Health Sciences Project Summary Download Summary Most physiological processes including feeding follow circadian (~24h) cycles. In mammals, these rhythms are generated by endogenous ‘body clocks’…
Contactless vital signs and movement monitoring and brain development in extremely premature infants- a translational study
Project Code MRCNMH25Br Chakkarapani Research Theme Neuroscience and Mental Health Project Summary Download Summary Currently used wired contact-based sensor system for vital sign monitoring in extremely premature babies, born before 28 weeks of pregnancy, could damage their skin and impede…
Understanding neuronal dysfunction in Tuberous Sclerosis
Project Code MRCNMH25Br Carroll Research Theme Neuroscience and Mental Health Project Summary Download Summary Mutations in the TSC1 gene lead to Tuberous Sclerosis (TS), a genetic disorder associated with severe neurological symptoms. However, how mutations in TSC1 affect the brain…
Do experiences in Virtual Reality change body perception and satisfaction, in individuals with and without eating disorders
Project Code MRCNMH25Br Bould Research Theme Neuroscience and Mental Health Project Summary Download Summary Current treatments for eating disorders work for less than half of those affected, so it is vital to develop novel treatments. Virtual Reality enables a unique…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code MRCIIAR25Br Van Der Kamp Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β-lactamases are not well understood,…
Small-Molecule G-Quadruplex (G4) Ligands as Candidate Antibacterials for Resistant Bacteria
Project Code MRCIIAR25Br Spencer Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Increasing resistance makes developing new antibiotics, that kill bacteria by different mechanisms from existing agents, a public health priority. G-quadruplexes (G4s) are specific nucleotide…
Exploring the modulation of Antioxidant Metabolism to target Adult T-Cell Leukaemia Induced by HTLV-1 Infection
Project Code MRCIIAR25Br Shytaj Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with limited treatment options. Our…
Investigating the mechanisms underlying Professional killer cell dysfunction in dengue
Project Code MRCIIAR25Br Rivino Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Dengue is a mosquito-borne virus infection now affecting half of the world’s population. There is no cure or broadly protective vaccine for dengue. During…
Exploring Communication Networks in Proteins to Enable Antibiotic Discovery
Project Code MRCIIAR25Br Oliveria Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Bacterial antibiotic resistance is a global public health crisis. New antibiotics for resistant organisms are urgently needed, but attempts to identify new molecular targets…