Project Code MRCNMH25Ex Gold Research Theme Neuroscience & Mental Health Project Summary Download Summary Mitochondria provide energy essential for life and are dependent on the delivery of proteins from the cytosol for their biogenesis, maintenance and regeneration. Defects in protein…
Artificial Intelligence-enhanced mobile Behavioural Activation therapy for Dementia and Mild cognitive impairment (AI-BADeM)
Project Code MRCNMH25Ex Fox Research Theme Neuroscience & Mental Health Project Summary Download Summary Dementia affects around 55 million people globally, often leading to depression and unhealthy behaviours like physical inactivity and social isolation. These issues can worsen cognitive decline…
Epigenetic mechanisms in stem cell models of Rett syndrome
Project Code MRCNMH25Ex Flynn Research Theme Neuroscience & Mental Health Project Summary Download Summary Rett syndrome (RTT) is a neurodevelopmental disorder that causes physical and mental disability from early childhood. It is characterised by impaired motor and cognitive function and…
Cell-type-specific epigenetic regulation of gene expression in Motor Neuron Disease
Project Code MRCNMH25Ex Dempster Research Theme Neuroscience & Mental Health Project Summary Download Summary This project aims to uncover new molecular insights into Motor Neuron Disease (MND) using advanced molecular technologies. It involves studying human post-mortem brain tissue and cells…
Enhancing stem cell-derived motor neuron function as a therapeutic approach in Amyotrophic Lateral Sclerosis
Project Code MRCNMH25Ex Brown Research Theme Neuroscience & Mental Health Project Summary Download Summary Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, for which there is currently no effective treatment. In this project, you will use human motor neurons…
Understanding the social brain circuits affected in neurodevelopmental disorders
Project Code MRCNMH25Ex Basson Research Theme Neuroscience & Mental Health Project Summary Download Summary The Kdm5b gene is linked to a number of neurodevelopmental disorders, including ADHD, autism, bipolar disorder and intellectual disability. Using a unique mouse model, we recently…
Developing in vitro and in vivo genetic models to study aberrant neuronal network activity in dementia
Project Code MRCNMH25Ex Nikolaou Research Theme Neuroscience and Mental Health Project Summary Download Summary Alzheimer’s disease (AD) is the leading cause of dementia characterized by memory loss and cognitive decline. Whilst cognitive decline in dementia is a progressive process affecting…