Understanding the interactions of Dengue virus with the immune system and its impact on disease

Project Code

MRCIIAR24Ca Fielding

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.

Summary

Natural killer (NK) cells are critical for killing virus-infected cells but can also cause immunopathology. This project investigates whether Dengue virus manipulates NK ligands to prevent NK cell killing and whether NK cells contribute to dengue pathogenesis. This has important implications for understanding NK cells and immunotherapy development. The student will receive cutting-edge training in virology, immunology, single cell RNA sequencing and proteomics.

Lead Supervisor

Dr Ceri Fielding

Lead Supervisor Email

fieldingca@cardiff.ac.uk

University Affiliation

Cardiff