Project Code CMD27Ca Fowler Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This project aims to address a research priority for patients with the inherited heart condition, hypertrophic cardiomyopathy (HCM), by investigating how the same mutation…
Decoding calcium signalling during fertilization: a data-driven mathematical modelling framework for a non-invasive IVF diagnostic tool
Project Code CMD27Ca Kaouri Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary In vitro fertilization (IVF) is the primary treatment for infertility, with over 2.5 million cycles performed annually worldwide. Success rates remain limited because the…
Investigation of human cytomegalovirus modulation of gamma delta T cells
Project Code IIAR27Ca Fielding Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Immune cells are important for the control of viral infections. In particular, innate cytotoxic lymphocytes such as gamma delta T-cells and…
Understanding cellular ageing of protective immunity to inform vaccine design and T-cell therapies
Project Code IIAR27Ca Ladell Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary The risk of dying from infection is particularly high in the elderly and is related to ageing of the immune system.…
Immune modulation of tonsillar Natural Killer cell immunity by Group A Streptococcus
Project Code IIAR27Ca McLaren Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary The human tonsils are crucial for producing neutralizing antibodies against infection yet are a breeding ground for Group A Streptococcus (GAS)…
Receptor to Remedy: Rewiring adenovirus-host protein dynamics to engineer next-generation nanomedicines
Project Code IIAR27Ca Parker Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary How do viruses hijack our cells, and how can we turn this process to our advantage? This project will explore the…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code IIAR27Ca Parmeggiani Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded…
Defining CD200 Function and the Therapeutic Potential of Targeting the CD200 immune checkpoint in Prostate Cancer
Project Code IIAR27Ca Pearson Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Prostate cancer remains a leading cause of cancer mortality, particularly in metastatic disease where treatment options are limited. This PhD project…
Optimising immune responses against emerging viruses
Project Code IIAR27Ca Stanton Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Worldwide, viruses that transmit to humans from biting insects account for ~17% of infectious diseases and ~700,000 deaths/yr, with ~4 billion…
Shared Genetic Architecture of Neuropsychiatric Disorders and Novel Brain Biomarkers: Towards Understanding Biological Processes
Project Code NMH27Ca Caseras Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary The field of imaging genetics has had limited success identifying shared common risk variants between mental disorders and brain phenotypes, this being…