Project Code NMH27Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Astrocytes are central regulators of brain function, controlling neuronal activity, metabolism, extracellular matrix organisation and resilience to disease. However, many astrocyte-enriched genes…
Chronic pain, sensory hypersensitivity and neurodiversity: why are they linked?
Project Code NMH27Ca Sumner Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Chronic pain conditions such as fibromyalgia, dysmenorrhea and back pain affect millions of people and severely disrupt daily life. An interesting but…
Mapping Cerebellar Network Dysfunction in Episodic Ataxia Using Human Organoids
Project Code NMH27Ca Syed Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project investigates how mutations in the KCNA1 gene cause Episodic Ataxia Type 1 (EA1), a rare neurological disorder characterised by impaired…
Pain as neurobiological surprise: Using human brain imaging and animal studies to advance new concepts in persistent pain.
Project Code NMH27Ca Tackley Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary We experience surprise when our best guess about the immediate future turns out to be wrong. This can be dangerous: it might mean…
Neural Dynamics of Perceptual Decision-Making During Robot-Mediated Motor Learning
Project Code NMH27Ca Zhou Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How does the brain make decisions while we are moving and learning? This PhD project will combine EEG, virtual reality and robotic…
Adaptive Virtual-Reality Exergaming for Physical and Cognitive Health in Older Adults
Project Code PHS27Ca Al-Amri Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Can virtual reality help older adults maintain physical and cognitive function? This project will develop and test SPIN‑VR, an interactive exercise game that…
Systematic investigation of the interaction of human cytomegalovirus with the immune system
Project Code MRCIIAR26Ca Fielding Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human cytomegalovirus (HCMV) is a herpesvirus that causes significant disease in individuals with impaired immune control. HCMV causes significant morbidity…
Understanding the dual roles of Wnt signalling in kidney injury, inflammation and repair following acute kidney injury
Project Code MRCIIAR26Ca Fraser Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary How does Wnt signalling determine tissue repair versus scarring following Acute Kidney Injury (AKI)? AKI is very common. Some people…
Immune modulation of tonsillar Natural Killer cell immunity by Group A Streptococcus
Project Code MRCIIAR26Ca McLaren Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The human tonsils are crucial for producing neutralizing antibodies against infection yet are a breeding ground for Group A Streptococcus…
Developing precision guided, viral based therapies using machine learning approaches
Project Code MRCIIAR26Ca Parker Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The Viral ImmunoTherapies and Advanced Therapeutics Laboratory engineers “smart viruses” for targeted treatment of cancer and genetic diseases. These viruses…