Project Code CMD27Ba Caixeiro Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises when chronic acid reflux causes the normal oesophageal lining to transform into intestinal-like…
Fat Quality as a Determinant of Cardiometabolic Risk During Ketogenic Diets
Project Code CMD27Ba Koumanov Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Very-low carbohydrate ketogenic diets (KDs) can improve body weight and blood glucose but often raise LDL-cholesterol levels, thereby increasing cardiovascular risk. A key unknown…
How Does Extreme Muscle Disuse Affect Whole-Body Health? Research Theme
Project Code CMD27Ba Maher Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Loss of muscle activity can happen through injury, illness or periods of hospitalisation. This rapidly disrupts the body’s ability to regulate blood sugar and…
Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health
Project Code CMD27Ba Méric Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Olfactory receptor (OR) genes are one of the largest gene families in the human genome, responsible for detecting food-related chemicals. While mostly expressed in…
Decoding the grammar of plasmid evolution: a hundred years of antibiotic resistance
Project Code IIAR27Ba Iqbal Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are mobile pieces of DNA that can spread between bacteria. They evolve by rearranging and swapping genes, and over the…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code IIAR27Ba Jones Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens. Working…
Designing Cell-Accumulating Covalent Inhibitors to Combat Gram-Negative Antimicrobial Resistance
Project Code IIAR27Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antimicrobial resistance is one of the greatest global health challenges, with Gram-negative bacteria particularly difficult to treat because their protective cell…
Turning up the volume: plasmid copy number and gene duplications as drivers of antimicrobial resistance evolution
Project Code IIAR27Ba Matlock Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are important drivers of antimicrobial resistance (AMR), complicating infections and causing outbreaks. Plasmids frequently alter their structure by duplicating genes,…
Do respiratory cilia sense and signal infection?
Project Code IIAR27Ba Preston Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Respiratory cilia are largely regarded as purely mechanical, sweeping particles trapped in mucus out of the respiratory tract. However, they contain…
Ion-channel communication: digital diagnostics for antimicrobial resistance
Project Code IIAR27Ba Reis Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacterial infections affect millions of people worldwide. Current methodologies for bacterial identification and antibiotic susceptibility testing (AST) are time consuming or…