Project Code IIAR27Br Dowsey Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Fungal infections have become a major and growing global health crisis, causing an estimated 3.8 million deaths each year particularly from…
When immune memory becomes corrupted
Project Code IIAR27Br Koh Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Our immune system has a remarkable ability to “remember” infections and diseases, helping us respond more effectively to future threats. Exciting…
Developing targeted covalent macrocycles to combat immune-mediated diseases
Project Code IIAR27Br Laabei Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage contributing…
Hidden codes: Genetic Determinants of HIV-1 Fitness and Immune Recognition
Project Code IIAR27Br Mann Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (CHIV)…
Deciphering Intramolecular Communication Networks to Identify New Antibiotic Targets in Multidrug-Resistant Bacteria
Project Code IIAR27Br Oliveira Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacteria are becoming resistant to many of our most important antibiotics, creating an urgent need for new treatments. This project will investigate…
Understanding beta-lactam antibiotic targets to improve melioidosis treatment
Project Code IIAR27Br Spencer Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Melioidosis, caused by the bacterium Burkholderia pseudomallei, is a severe, frequently fatal, tropical disease. Beta-lactam antibiotics are cornerstones of melioidosis treatment,…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code IIAR27Br Van der Kamp Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β- lactamases are…