Project Code
IIAR27Br Van der Kamp
Project Type
Other
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β- lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. By combining computer simulation (molecular dynamics, reaction simulations) and experimental methods (enzyme assays, crystallography) you will study how, finding links between structure and activity. This will help to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria.
Can the project be completed part time?
Yes
Lead Supervisor
Professor Marc Van der Kamp
Lead Supervisor Email
University Affiliation
University of Bristol
