Project Code
IIAR27Ca Fielding
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Immune cells are important for the control of viral infections. In particular, innate cytotoxic lymphocytes such as gamma delta T-cells and natural killer (NK) are able to sense healthy tissue and kill tumour and viral-infected cells. This process is controlled by cues they receive from protein receptors on their cell surface that either provide activating or inhibitory signals telling them to leave healthy cells alone or kill virusinfected cells they encounter. This project will investigate how an important human pathogen, human cytomegalovirus (HCMV), modulates the activation of enigmatic gamma delta T-cells and the impact on the control of HCMV-mediated disease.
Can the project be completed part time?
No
Lead Supervisor
Dr Ceri Fielding
Lead Supervisor Email
University Affiliation
Cardiff University
