Project Code CMD27Br Biglino Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Congenital heart disease (CHD) affects 1 in 110 births and causes significant long-term morbidity, yet identifying anatomical subphenotypes remains difficult. Structural changes over time—…
Understanding the role of immunometabolic changes and immune exhaustion during recovery of paediatric cardiac bypass surgery
Project Code CMD27Br Caputo Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary 1 in 300 babies born in the UK will require surgery for congenital heart disease. Although cardiopulmonary bypass has transformed survival, recovery varies considerably,…
Understanding the link between lipid droplet biology and bone health
Project Code CMD27Br Carroll Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cells require a tightly regulated supply of lipids to sustain metabolism and growth. When lipids are abundant, fatty acids are packaged into lipid droplets,…
How the Golgi Feels Force: Uncovering a Hidden Driver of Osteoarthritis
Project Code CMD27Br Hammond Project Type Other Research Theme Cardiometabolic Disease Project Summary Download Summary Globally, 600 million people live with osteoarthritis, a disease driven by cartilage breakdown. One major disease risk factor is abnormal mechanical loading of joints, yet…
Vascular morphology and haemodynamic risk of intracranial aneurysm in aortic coarctation
Project Code CMD27Br Hart Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Aortic coarctation (CoA) is a common congenital heart disease, and even after successful repair, patients face elevated lifelong risk of hypertension, stroke, and intracranial…
Brain-heart connections: how astrocytes shape the cardiovascular protective effects of GLP-1
Project Code CMD27Br Mastitskaya Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This PhD project will investigate how glucagon-like peptide-1 (GLP-1), a hormone central to metabolism, interacts with astrocytes – supportive “star-shaped” brain cells – to…
Cardiac glia: gatekeepers of the stressed heart?
Project Code CMD27Br Mosienko Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary The heart is controlled by the peripheral nervous system, whose nerves are supported by “helper” cells called glia, as astrocytes support neurons in the…
Targeted gene integration therapy for cystinosis
Project Code CMD27Br Saleem Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cystinosis is a rare condition caused by mutations in the CTNS gene. This leads to cystine build-up in cells which damages many organs, especially…