Project Code CMD27Ba Caixeiro Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises when chronic acid reflux causes the normal oesophageal lining to transform into intestinal-like…
Fat Quality as a Determinant of Cardiometabolic Risk During Ketogenic Diets
Project Code CMD27Ba Koumanov Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Very-low carbohydrate ketogenic diets (KDs) can improve body weight and blood glucose but often raise LDL-cholesterol levels, thereby increasing cardiovascular risk. A key unknown…
How Does Extreme Muscle Disuse Affect Whole-Body Health? Research Theme
Project Code CMD27Ba Maher Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Loss of muscle activity can happen through injury, illness or periods of hospitalisation. This rapidly disrupts the body’s ability to regulate blood sugar and…
Understanding the role of immunometabolic changes and immune exhaustion during recovery of paediatric cardiac bypass surgery
Project Code CMD27Br Caputo Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary 1 in 300 babies born in the UK will require surgery for congenital heart disease. Although cardiopulmonary bypass has transformed survival, recovery varies considerably,…
Understanding the link between lipid droplet biology and bone health
Project Code CMD27Br Carroll Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cells require a tightly regulated supply of lipids to sustain metabolism and growth. When lipids are abundant, fatty acids are packaged into lipid droplets,…
How the Golgi Feels Force: Uncovering a Hidden Driver of Osteoarthritis
Project Code CMD27Br Hammond Project Type Other Research Theme Cardiometabolic Disease Project Summary Download Summary Globally, 600 million people live with osteoarthritis, a disease driven by cartilage breakdown. One major disease risk factor is abnormal mechanical loading of joints, yet…
Brain-heart connections: how astrocytes shape the cardiovascular protective effects of GLP-1
Project Code CMD27Br Mastitskaya Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This PhD project will investigate how glucagon-like peptide-1 (GLP-1), a hormone central to metabolism, interacts with astrocytes – supportive “star-shaped” brain cells – to…
Cardiac glia: gatekeepers of the stressed heart?
Project Code CMD27Br Mosienko Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary The heart is controlled by the peripheral nervous system, whose nerves are supported by “helper” cells called glia, as astrocytes support neurons in the…
Targeted gene integration therapy for cystinosis
Project Code CMD27Br Saleem Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cystinosis is a rare condition caused by mutations in the CTNS gene. This leads to cystine build-up in cells which damages many organs, especially…
Linking structure, function and genomics at single cell resolution: an integrative approach to understanding inherited heart disease
Project Code CMD27Ca Fowler Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This project aims to address a research priority for patients with the inherited heart condition, hypertrophic cardiomyopathy (HCM), by investigating how the same mutation…