Project Code CMD27Ex Podlogar Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Ketogenic diet (very low in carbohydrate, high in fat) is increasingly popular among people with Type 1 Diabetes (T1D). In principle, a ketogenic diet…
Understanding Muscle Metabolism Responses to Feeding in Adult Survivors of Childhood Acute lymphoblastic Leukaemia
Project Code CMD27Ex Revuelta Iniesta Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty (age 44) defined by muscle atrophy. Muscle protein synthesis is crucial for muscle…
Sex-Specific Cardiac Remodelling in Female Athletes: Unravelling Cardiometabolic Risk and Long-Term Health Outcomes
Project Code CMD27Ex Williams Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This project tackles a major challenge in biomedical research: the historical under-representation of women in cardiovascular and sports science. Much of what we know…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code IIAR27Ba Jones Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens. Working…
Designing Cell-Accumulating Covalent Inhibitors to Combat Gram-Negative Antimicrobial Resistance
Project Code IIAR27Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antimicrobial resistance is one of the greatest global health challenges, with Gram-negative bacteria particularly difficult to treat because their protective cell…
Turning up the volume: plasmid copy number and gene duplications as drivers of antimicrobial resistance evolution
Project Code IIAR27Ba Matlock Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are important drivers of antimicrobial resistance (AMR), complicating infections and causing outbreaks. Plasmids frequently alter their structure by duplicating genes,…
Do respiratory cilia sense and signal infection?
Project Code IIAR27Ba Preston Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Respiratory cilia are largely regarded as purely mechanical, sweeping particles trapped in mucus out of the respiratory tract. However, they contain…
Ion-channel communication: digital diagnostics for antimicrobial resistance
Project Code IIAR27Ba Reis Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacterial infections affect millions of people worldwide. Current methodologies for bacterial identification and antibiotic susceptibility testing (AST) are time consuming or…
Reprogramming Antibodies: Novel Chemical Re-bridging to Overcome Immune Resistance in the Tumour Microenvironment
Project Code IIAR27Ba Watts Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antibodies are powerful medicines that are used to guide the immune system to fight cancer. However, standard antibodies sometimes activate the…
When immune memory becomes corrupted
Project Code IIAR27Br Koh Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Our immune system has a remarkable ability to “remember” infections and diseases, helping us respond more effectively to future threats. Exciting…