Project Code
CMD27Ca Fowler
Project Type
Wet lab
Research Theme
Cardiometabolic Disease
Project Summary Download
Summary
This project aims to address a research priority for patients with the inherited heart condition, hypertrophic cardiomyopathy (HCM), by investigating how the same mutation can result in widely different phenotypes. Increased variability can manifest between different individuals, regions of the heart, and from one cell to the next. To address this, you will develop a unique process for capturing structural (confocal microscopy), functional (electrophysiology and Ca2+ imaging), and transcriptomic data all from the same cell. Integrating function and genomics will provide unprecedented power to identify possible causal factors responsible for pathology, and opportunities for intervention.
Can the project be completed part time?
No
Lead Supervisor
Dr Ewan Fowler
Lead Supervisor Email
University Affiliation
Cardiff University
