Project Code CMD27Ba Méric Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Olfactory receptor (OR) genes are one of the largest gene families in the human genome, responsible for detecting food-related chemicals. While mostly expressed in…
Novel dynamic shape atlasing of cardiovascular structures in congenital heart disease
Project Code CMD27Br Biglino Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Congenital heart disease (CHD) affects 1 in 110 births and causes significant long-term morbidity, yet identifying anatomical subphenotypes remains difficult. Structural changes over time—…
How the Golgi Feels Force: Uncovering a Hidden Driver of Osteoarthritis
Project Code CMD27Br Hammond Project Type Other Research Theme Cardiometabolic Disease Project Summary Download Summary Globally, 600 million people live with osteoarthritis, a disease driven by cartilage breakdown. One major disease risk factor is abnormal mechanical loading of joints, yet…
Vascular morphology and haemodynamic risk of intracranial aneurysm in aortic coarctation
Project Code CMD27Br Hart Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Aortic coarctation (CoA) is a common congenital heart disease, and even after successful repair, patients face elevated lifelong risk of hypertension, stroke, and intracranial…
Decoding calcium signalling during fertilization: a data-driven mathematical modelling framework for a non-invasive IVF diagnostic tool
Project Code CMD27Ca Kaouri Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary In vitro fertilization (IVF) is the primary treatment for infertility, with over 2.5 million cycles performed annually worldwide. Success rates remain limited because the…
Disentangling Diabetes: A Novel Genetic Decomposition Approach
Project Code CMD27Ex Beaumont Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Diabetes is a highly heterogeneous condition, but its clinical management relies heavily on HbA1c – a biomarker affected by distinct pathways: glucose metabolism (glycaemic)…
Data-Driven Precision Medicine in the Hospital: Advanced Blood Glucose Analytics to Improve Inpatient Diabetes Care
Project Code CMD27Ex Dennis Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary 20%-30% of NHS hospital beds are occupied by people with diabetes, who often experience poorer clinical outcomes due to unstable blood sugar levels (adverse…
Understanding the causes, and best treatment, of type 2 diabetes in people who are not overweight
Project Code CMD27Ex Jones Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Many people think of type 2 diabetes as being a condition that affects people with high body weight, but millions of people with type…
Genetic and Therapeutic Determinants of Adverse Drug Reactions in Cardio-Renal Diseases
Project Code CMD27Ex Pilling Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Why do people with cardiometabolic diseases experience different health trajectories despite similar treatment? This interdisciplinary PhD project will investigate how genetic variation, prescribing, and…
Decoding the grammar of plasmid evolution: a hundred years of antibiotic resistance
Project Code IIAR27Ba Iqbal Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are mobile pieces of DNA that can spread between bacteria. They evolve by rearranging and swapping genes, and over the…