Project Code IIAR27Br Dowsey Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Fungal infections have become a major and growing global health crisis, causing an estimated 3.8 million deaths each year particularly from…
Deciphering Intramolecular Communication Networks to Identify New Antibiotic Targets in Multidrug-Resistant Bacteria
Project Code IIAR27Br Oliveira Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Bacteria are becoming resistant to many of our most important antibiotics, creating an urgent need for new treatments. This project will investigate…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code IIAR27Br Van der Kamp Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β- lactamases are…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code IIAR27Ca Parmeggiani Project Type Other Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded…
How pathogens emerge: integrating large language models with comparative genomics to uncover the zoonotic potential of bacteria
Project Code IIAR27Ex Vos Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Most emerging bacterial pathogens originate from animal hosts (are ‘zoonotic’), yet it is hard to predict which pathogen species are likely…
Understanding and improving the provision of clinical services for youth with disruptive behaviour disorders
Project Code NMH27Ba Fairchild Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This PhD project will involve mapping mental health service provision for children and young people with disruptive behaviour disorders through a nationally…
Transdiagnostic mental health interventions for adversity affected youth
Project Code NMH27Ba Halligan Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Young people exposed to adversity are at risk of a range of mental health problems including anxiety, depression and conduct-related problems, making…
Parental transmission of substance use: exploring mechanisms and informing intervention
Project Code NMH27Ba Hines Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Reducing substance use is a key goal within public health. Recent work has shown that a strong predictor of adolescent substance use…
Beyond Pain Intensity: Ecological Measurement and Neurostimulation of Pain-Related Motor Interference
Project Code NMH27Ba Khatibi Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary This project will develop and validate an ecologically meaningful measure of pain-related interference with motor function. Rather than relying on simple laboratory tasks…
The brain-skin link in psychosis: uncovering shared biology and new treatment targets
Project Code NMH27Ba Lancaster Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Severe mental illnesses (e.g. schizophrenia/bipolar disorder) affect the whole body, not just the brain – and share genetic links with inflammatory conditions,…