Project Code
IIAR27Br Oliveira
Project Type
Other
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Bacteria are becoming resistant to many of our most important antibiotics, creating an urgent need for new treatments. This project will investigate how proteins communicate internally to control their function, focusing on DNA gyrase, a key bacterial enzyme and major antibiotic target. Using advanced computer simulations alongside experiments, this project will uncover how structural changes travel through this molecular machine, how resistance mutations alter these pathways, and how new drugs could disrupt them. The project offers training at the interface of computational chemistry, biophysics, structural biology, and antibiotic discovery, opening the door to the next-generation antibacterial therapies.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Sofia Oliveira
Lead Supervisor Email
University Affiliation
University of Bristol
