Project Code CMD27Ba Caixeiro Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises when chronic acid reflux causes the normal oesophageal lining to transform into intestinal-like…
Understanding the impact of olfactory genetics, diet and gut microbiota on cardiometabolic health
Project Code CMD27Ba Méric Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Olfactory receptor (OR) genes are one of the largest gene families in the human genome, responsible for detecting food-related chemicals. While mostly expressed in…
Novel dynamic shape atlasing of cardiovascular structures in congenital heart disease
Project Code CMD27Br Biglino Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Congenital heart disease (CHD) affects 1 in 110 births and causes significant long-term morbidity, yet identifying anatomical subphenotypes remains difficult. Structural changes over time—…
Understanding the role of immunometabolic changes and immune exhaustion during recovery of paediatric cardiac bypass surgery
Project Code CMD27Br Caputo Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary 1 in 300 babies born in the UK will require surgery for congenital heart disease. Although cardiopulmonary bypass has transformed survival, recovery varies considerably,…
Understanding the link between lipid droplet biology and bone health
Project Code CMD27Br Carroll Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cells require a tightly regulated supply of lipids to sustain metabolism and growth. When lipids are abundant, fatty acids are packaged into lipid droplets,…
How the Golgi Feels Force: Uncovering a Hidden Driver of Osteoarthritis
Project Code CMD27Br Hammond Project Type Other Research Theme Cardiometabolic Disease Project Summary Download Summary Globally, 600 million people live with osteoarthritis, a disease driven by cartilage breakdown. One major disease risk factor is abnormal mechanical loading of joints, yet…
Vascular morphology and haemodynamic risk of intracranial aneurysm in aortic coarctation
Project Code CMD27Br Hart Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Aortic coarctation (CoA) is a common congenital heart disease, and even after successful repair, patients face elevated lifelong risk of hypertension, stroke, and intracranial…
Cardiac glia: gatekeepers of the stressed heart?
Project Code CMD27Br Mosienko Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary The heart is controlled by the peripheral nervous system, whose nerves are supported by “helper” cells called glia, as astrocytes support neurons in the…
Targeted gene integration therapy for cystinosis
Project Code CMD27Br Saleem Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Cystinosis is a rare condition caused by mutations in the CTNS gene. This leads to cystine build-up in cells which damages many organs, especially…
Decoding calcium signalling during fertilization: a data-driven mathematical modelling framework for a non-invasive IVF diagnostic tool
Project Code CMD27Ca Kaouri Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary In vitro fertilization (IVF) is the primary treatment for infertility, with over 2.5 million cycles performed annually worldwide. Success rates remain limited because the…