Project Code CMD27Ex Beaumont Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Diabetes is a highly heterogeneous condition, but its clinical management relies heavily on HbA1c – a biomarker affected by distinct pathways: glucose metabolism (glycaemic)…
Data-Driven Precision Medicine in the Hospital: Advanced Blood Glucose Analytics to Improve Inpatient Diabetes Care
Project Code CMD27Ex Dennis Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary 20%-30% of NHS hospital beds are occupied by people with diabetes, who often experience poorer clinical outcomes due to unstable blood sugar levels (adverse…
Understanding the causes, and best treatment, of type 2 diabetes in people who are not overweight
Project Code CMD27Ex Jones Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Many people think of type 2 diabetes as being a condition that affects people with high body weight, but millions of people with type…
Genetic and Therapeutic Determinants of Adverse Drug Reactions in Cardio-Renal Diseases
Project Code CMD27Ex Pilling Project Type Dry lab Research Theme Cardiometabolic Disease Project Summary Download Summary Why do people with cardiometabolic diseases experience different health trajectories despite similar treatment? This interdisciplinary PhD project will investigate how genetic variation, prescribing, and…
Metabolic adaptation to a low carbohydrate ketogenic diet and its effects on exercise fuel use and glucose management in physically active people with Type 1 Diabetes
Project Code CMD27Ex Podlogar Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Ketogenic diet (very low in carbohydrate, high in fat) is increasingly popular among people with Type 1 Diabetes (T1D). In principle, a ketogenic diet…
Understanding Muscle Metabolism Responses to Feeding in Adult Survivors of Childhood Acute lymphoblastic Leukaemia
Project Code CMD27Ex Revuelta Iniesta Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty (age 44) defined by muscle atrophy. Muscle protein synthesis is crucial for muscle…
Sex-Specific Cardiac Remodelling in Female Athletes: Unravelling Cardiometabolic Risk and Long-Term Health Outcomes
Project Code CMD27Ex Williams Project Type Wet lab Research Theme Cardiometabolic Disease Project Summary Download Summary This project tackles a major challenge in biomedical research: the historical under-representation of women in cardiovascular and sports science. Much of what we know…
Decoding the grammar of plasmid evolution: a hundred years of antibiotic resistance
Project Code IIAR27Ba Iqbal Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are mobile pieces of DNA that can spread between bacteria. They evolve by rearranging and swapping genes, and over the…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code IIAR27Ba Jones Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens. Working…
Turning up the volume: plasmid copy number and gene duplications as drivers of antimicrobial resistance evolution
Project Code IIAR27Ba Matlock Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Plasmids are important drivers of antimicrobial resistance (AMR), complicating infections and causing outbreaks. Plasmids frequently alter their structure by duplicating genes,…