Project Code
IIAR27Br Laabei
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage contributing to many autoimmune and inflammatory diseases. Despite its therapeutic potential, few complement-targeting drugs have been approved for clinical use. Selective inhibition of key complement proteins offers a promising approach. This proposal aims to develop targeted covalent macrocycle inhibitors of complement serine proteases using molecular, chemical, and structural biology tools, advancing next generation complement therapies toward clinical application.
Can the project be completed part time?
No
Lead Supervisor
Dr Maisem Laabei
Lead Supervisor Email
University Affiliation
University of Bristol
