Project Code
NMH27Ca Syed
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
This project investigates how mutations in the KCNA1 gene cause Episodic Ataxia Type 1 (EA1), a rare neurological disorder characterised by impaired motor coordination. Using patient-derived induced pluripotent stem cells (iPSCs), you will generate three-dimensional human cerebellar organoids to model early brain development and disease mechanisms. The research aims to determine how KCNA1 mutations disrupt neuronal differentiation, synaptic connectivity, and neural network function. Working within a multidisciplinary team specialising in advanced stem cell models of neurological disease, you will receive training in iPSC differentiation, organoid culture, and highresolution bioimaging while contributing to the development of future therapeutic strategies.
Can the project be completed part time?
No
Lead Supervisor
Dr Yasir Ahmed Syed
Lead Supervisor Email
University Affiliation
Cardiff University
