Investigating Neurodevelopmental Disorders Through the Lens of UPF3B Syndrome

Project Code MRCNMH26Ca Ngo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodevelopmental disorders (NDDs) like autism and ADHD affect millions, yet the underlying causes remain unclear. This PhD project investigates how mutations in…

Novel area-modulation stimuli for identifying changes in visual field sensitivity in Age-related Macular Degeneration (AMD)

Project Code MRCNMH26Ca Redmond Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Age-related macular degeneration (AMD) is one of the world’s leading causes of sight loss. Traditional measures of vision in AMD are of…

When DNA Breaks and Mitochondria Fail: Investigating Drivers of Huntington’s Disease

Project Code MRCNMH26Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a fatal inherited brain disorder with no effective treatment. It causes specific neurons in the brain to degenerate,…

Pain as neurobiological surprise: Using human brain imaging and animal studies to advance new concepts in persistent pain.

Project Code MRCNMH26Ca Tackley Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Complex nervous systems attempt to minimise surprise and aid survival by forming predictions about the world. Surprise signals danger: it is evidence…

Optimising awareness of, access to, and uptake of HIV pre-exposure prophylaxis among underserved communities in the UK

Project Code MRCPHS26Ca Gillespie Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary This PhD project addresses persistent inequities in access to HIV pre-exposure prophylaxis (PrEP) in the UK. Through a multi-stage approach—comprising a literature review,…

Leveraging pregnancy cohort data to investigate the link between placental hormones and adverse pregnancy outcomes

Project Code MRCPHS26Ca John Project Type Dry lab Research Theme Population Health Science Project Summary Download Summary Low birth weight (LBW) infants are at an increased risk of dying, and those who survive are more likely to experience poor health…

Maternal anxiety and language delays in children – both outcomes of the same epigenetic alteration?

Project Code MRCNMH25Ca John Research Theme Neuroscience and Mental Health Project Summary Download Summary Maternal depression and anxiety are highly common in pregnancy and associated with a negative effect on the child’s social and language skills. This PhD will test…

Calcium signalling in In-Vitro Fertilization: developing a non-invasive diagnostic tool

Project Code MRCPHS25Ca Kaouri Research Theme Population Health Sciences Project Summary Download Summary In-Vitro Fertilization is the primary treatment of infertility, with ~2.5 million cycles performed annually. Success rates are, however, declining partly due to waiting 5 days to select…

Targeted reprogramming of epigenetic signals for lung regeneration

Project Code MRCPHS25Ca Jurkowska Research Theme Population Health Sciences Project Summary Download Summary What most of us do naturally and take for granted – the breathing – 500 million people struggle with as they suffer from incurable lung disease. Epigenetic…

Improving Bruise Evidence Across Variations in Skin Tone Using Artificial Intelligence

Project Code MRCPHS25Ca Farnell Research Theme Population Health Sciences Project Summary Download Summary Bruises are often seen on victims of violence in accident and emergency departments or as part of paediatric examinations. Bruising predicts later hospitalisation and homicide. Collecting reliable…