Project Code
MRCNMH26Ba Licchesi
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Targeted Protein Degradation (TPD) is a new approach that helps cells remove harmful proteins linked to diseases like Alzheimer’s. It uses special molecules that bring the disease-causing protein close to the cell’s natural disposal system, triggering its breakdown. This project will use knowledge of how cells tag and remove proteins to design new tools that target mutant Tau, a protein linked to dementia. The student will work across biochemistry and cellular neuroscience to create and test these tools in lab-grown brain cells, studying how removing mutant Tau affects neuron health and brain cell function in models of Alzheimer’s disease.
Lead Supervisor
Dr Julien Licchesi
Lead Supervisor Email
University Affiliation
Bath