Project Code
MRCNMH26Ba Vance
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
The mammalian genome encodes hundreds of RNA binding proteins that associate with RNA using poorly defined modes of action. Mutations in these are implicated in neurologic disorders including amyotrophic lateral sclerosis and fragile X syndrome. KAP1 is an essential chromatin regulator and unconventional RNA binding protein required for neural stem cell maintenance and neuronal differentiation. KAP1-long non-coding RNA interactions broadly impact KAP1 chromatin and transcriptional regulation. This project will investigate RNA-dependent KAP1 gene expression control of neural stem cell function and nerve cell production and is important for the development of new treatments for neurological disorders.
Lead Supervisor
Dr Keith Vance
Lead Supervisor Email
University Affiliation
Bath