Project Code
MRCNMH26Br Cross
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Intracellular transport is essential for organising and maintaining the function of eukaryotic cells. This is particularly important in neurons, where cargo must be moved efficiently over long distances. Transport is driven by kinesin and dynein motor proteins which travel along microtubules to deliver organelles, proteins, and RNAs to precise locations. Disruption of this system is linked to numerous neurological disorders. This PhD will design synthetic protein modulators to achieve acute, isoform specific control of kinesin 1 activity in cells. Precise modulation of kinesin-1 will offer mechanistic insights into neurodegenerative transport defects and may offer routes to new classes of therapeutics.
Lead Supervisor
Dr Jessica Cross
Lead Supervisor Email
University Affiliation
Bristol