Maternal anxiety and language delays in children – both outcomes of the same epigenetic alteration?

Project Code MRCNMH25Ca John Research Theme Neuroscience and Mental Health Project Summary Download Summary Maternal depression and anxiety are highly common in pregnancy and associated with a negative effect on the child’s social and language skills. This PhD will test…

Calcium signalling in In-Vitro Fertilization: developing a non-invasive diagnostic tool

Project Code MRCPHS25Ca Kaouri Research Theme Population Health Sciences Project Summary Download Summary In-Vitro Fertilization is the primary treatment of infertility, with ~2.5 million cycles performed annually. Success rates are, however, declining partly due to waiting 5 days to select…

Targeted reprogramming of epigenetic signals for lung regeneration

Project Code MRCPHS25Ca Jurkowska Research Theme Population Health Sciences Project Summary Download Summary What most of us do naturally and take for granted – the breathing – 500 million people struggle with as they suffer from incurable lung disease. Epigenetic…

Improving Bruise Evidence Across Variations in Skin Tone Using Artificial Intelligence

Project Code MRCPHS25Ca Farnell Research Theme Population Health Sciences Project Summary Download Summary Bruises are often seen on victims of violence in accident and emergency departments or as part of paediatric examinations. Bruising predicts later hospitalisation and homicide. Collecting reliable…

Biomarker discovery of inflammatory pathways linked to mood and autoimmune disorders

Project Code MRCNMH25Ca Szomolay Research Theme Neuroscience & Mental Health Project Summary Download Summary “Mood disorders (MDs), e.g. depression, affect over one billion people worldwide. MDs show a bidirectional relationship with systemicinflammation, a key component in the pathophysiology of autoimmune…

How does DNA damage and mitochondrial dysfunction contribute to Huntington’s disease?

Project Code MRCNMH25Ca Smith Research Theme Neuroscience & Mental Health Project Summary Download Summary Huntington’s disease (HD) is an inherited disorder that causes specific neurons in the brain to die. HD patients develop uncontrollable movements as well as cognitive and…

AI-enhanced Quantitative MRI for Multi-Scale Multi-Modal Neuroscience

Project Code MRCNMH25Ca Slator Research Theme Neuroscience & Mental Health Project Summary Download Summary This project will develop advanced machine learning methods for medical imaging to non-invasively characterise brain tissue structure and function. The project focuses on quantitative MRI, which…

Enabling continuous, personalised stress quantification and management with a wearable system

Project Code MRCNMH25Ca Pham Research Theme Neuroscience & Mental Health Project Summary Download Summary Nine in ten adults in the UK suffer from high or extreme stress in 2023. Stress-related disorders and burnout cost the UK economy more than £28…

Developing a new therapeutic strategy for brain cancers: getting therapeutics directly to the tumour

Project Code MRCNMH25Ca Newland Research Theme Neuroscience & Mental Health Project Summary Download Summary Some brain cancers cannot be surgically removed, and many potent therapeutics cannot reach the tumour site. This project aims to overcome these hurdles by utilizing a…