Project Code MRCNMH25Ca Mehellou Research Theme Neuroscience & Mental Health Project Summary Download Summary “Parkinson’s disease (PD) is the second most common neurological disease in the world. Current PD therapies and medical interventions are limited to addressing the symptoms of…
Using MRI, MEG, and machine learning to better classify severe mental illness
Project Code MRCNMH25Ca McNabb Research Theme Neuroscience & Mental Health Project Summary Download Summary Clinical diagnoses of severe mental illnesses currently rely solely on symptom report and poorly predict long-term outcomes. This PhD project aims to integrate information from brain…
Using a new translational in vivo model to understand the neurobiology underlying ADHD subtypes
Project Code MRCNMH25Ca Davies Research Theme Neuroscience & Mental Health Project Summary Download Summary In mice and humans loss-of-function of the steroid sulfatase (STS) enzyme results in inattention but enhanced motor response inhibition; we aim to understand the neurobiology underlying…
Unlocking the causes of eating disorders: investigating risk factors across development
Project Code MRCNMH25Ca Chawner Research Theme Neuroscience & Mental Health Project Summary Download Summary Tackling eating disorders is of growing importance in society, with increasing numbers of children and young people referred to eating disorder services. This PhD project focuses…
Neonatal Sepsis Detection Automation for Neonatal Intensive Care Units.
Project Code MRCIIAR25Ca Woolley Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Sepsis is a leading cause of death in infants, particularly in Neonatal Intensive Care Units (NICUs). Early detection is crucial for improving recovery chances.…
Enhancing Immunological Control of SARS-CoV-2
Project Code MRCIIAR25Ca Stanton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Neutralizing antibodies are key to preventing transmission of SARS-CoV-2, however the virus can rapidly mutate to avoid these. Furthermore, once infected, neutralizing antibodies cannot…
New antibiotics to kill “Superbugs” by stopping them from dividing
Project Code MRCIIAR25Ca Serpi Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary While antibiotics have revolutionised the landscape of medicine saving millions of lives, their misuse has also resulted in the rise of “Superbugs”, which are…
Design, synthesis and biological evaluation of molecules to tackle invasive fungal infections
Project Code MRCIIAR25Ca Pertusati Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal infections are a major threat to public health as they are becoming increasingly resistant to treatment. Only four classes of antifungals are available,…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code MRCIIAR25Ca Parmeggiani Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded in a…
T cell immune modulation during severe bacterial infection
Project Code MRCIIAR25Ca McLaren Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary There is no licenced vaccine against Staphylococcus aureus which produces life-threatening bloodstream infections (“bacteraemia”) and has evolved antibiotic-resistant strains. However, mucosal-associated invariant T (MAIT)…