Project Code
MRCIIAR26Ba Preston
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Most current antibiotics are derivatives of previous drugs and resistance adapts quickly to the new derivatives, greatly limiting their useful lifespan. New antibiotics with novel bacterial targets are desperately needed. In this project we will develop bacterial nutrient transporters as novel antibiotic targets. Inhibiting nutrient uptake will slow bacterial growth, allowing immune responses to clear the infection, and/or augmenting current antibiotic use. As proof-of-principle for this approach we will use metabolic modeling to identify target transporters, genetic engineering and novel peptide inhibitors to drug them and single cell imaging to test the effects of this on cell growth and viability.
Lead Supervisor
Professor Andrew Preston
Lead Supervisor Email
University Affiliation
Bath