Project Code
MRCNMH26Ex Guo
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
This project aims to uncover how early human immune cells, especially microglia (the brain’s immune cells), form during development. Since studying human embryos directly is not possible, you will use a recently established stem cell system that mimics early embryonic conditions to generate these cells in the lab. By defining the signals guiding their development, you will create reliable methods to produce microglia and test their functions. This research will enhance our understanding of the initial stages of blood formation, as well as the brain’s immune system, and enable the development of patient-specific microglia models for neurodegenerative diseases.
Lead Supervisor
Dr Ge Guo
Lead Supervisor Email
University Affiliation
Exeter