Project Code
MRCNMH25Ex Witton
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
Microglia are brain-resident immune cells. Alongside conventional molecular signals, the latest research suggests that specific patterns of brain activity can control microglia function. We have found that a type of brain activity normally activated during cognition (called gamma oscillations) signals to microglia via a receptor subgroup, which may drive a neuroprotective response. Using a novel experimental assay developed by our lab, this project will uncover how this signalling works to reveal new drug targets for treating conditions where immune systems in the brain malfunction, such as in Alzheimer’s disease.
Lead Supervisor
Dr Jonathan Witton
Lead Supervisor Email
j.witton@exeter.ac.uk
University Affiliation
Exeter