Project Code
MRCNMH24Ex Witton
Research Theme
Neuroscience and Mental Health
Full Project Description
Please download the below document for a full project description and to see the full supervisory team.
Summary
Microglia are brain-resident immune cells. Alongside conventional molecular signals, evidence suggests that specific patterns of brain activity can control microglia function. We have found that a type of brain activity activated during cognition (called gamma oscillations) signals to microglia via a receptor subgroup, which may drive a neuroprotective response. This project will uncover how this signalling works to reveal drug targets for neurodegenerative disease.
Lead Supervisor
Dr Jonathan Witton
Lead Supervisor Email
j.witton@exeter.ac.uk
University Affiliation
Exeter