Project Code
MRCIIAR26Ba Jones
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens. Working with the United Kingdom Health Security Agency, you will employ molecular, genomic, bioinformatic, and directed evolution techniques, in conjunction with models of polymicrobial infection, to answer fundamental questions about the co-evolution of bacteriophage within bacterial microbiomes. These studies are essential to understand how we could apply bacteriophage to treat problematic infections, including those which are antibiotic resistant. They also open up opportunities to use phage for microbiome modulation as a new way of preventing infections.
Lead Supervisor
Dr Brian Jones
Lead Supervisor Email
University Affiliation
Bath