Project Code
MRCIIAR26Ba Caixeiro
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises from chronic acid reflux. It involves the transformation of the oesophageal lining into an intestinal-like tissue, though its cellular origin and underlying mechanisms remain unclear. This project uses organ-on-a-chip models to study how cells respond to molecular drivers of BM. Individual cells will be tagged with microlasers for optical tracking, enabling detailed analysis of migration and behaviour over time. Lab-on-a-chip devices will then be used to sort cells in a microfluidic device and perform single-cell genetic profiling. These insights aim to reveal BM’s origins and inform future therapeutic strategies.
Lead Supervisor
Dr Soraya Caixeiro
Lead Supervisor Email
University Affiliation
Bath