Project Code
MRCIIAR25Ca Pertusati
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Fungal infections are a major threat to public health as they are becoming increasingly resistant to treatment. Only four classes of antifungals are available, with few candidates in the clinical pipeline. Fungal diseases can also damage plants and crops, causing major losses in agricultural activities and food production. The discovery of new antifungals is therefore an urgent need. From a small library of molecules, we have identified two classes of compounds (including an approved drug) with antifungal effect, and we aim to improve their activity via structure-activity-relationships. Identification of drug’s biological target is also a goal for this project.
Lead Supervisor
Dr Fabrizio Pertusati
Lead Supervisor Email
pertusatif1@cardiff.ac.uk
University Affiliation
Cardiff