Project Code
MRCPHS26Br Rayfield
Project Type
Wet lab
Research Theme
Population Health Science
Project Summary Download
Summary
This project explores how joints respond to mechanical forces throughout life, using zebrafish as a model to understand joint ageing and degeneration. By combining advanced imaging and mechanical testing, the student will study how joint shape, genetics, and tissue properties influence joint health in wild type and mutant fish. Computer models will predict how these factors affect strain and wear in the jaw. The aim is to uncover how joint tissue degradation with age and mutation of osteoarthritis susceptibility genes affects jaw mechanics, informing new strategies for improving joint health in ageing humans and animals.
Lead Supervisor
Professor Emily Rayfield
Lead Supervisor Email
University Affiliation
Bristol