Project Code
MRCIIAR26Ex van Houte
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids (mobile pieces of DNA) that facilitate AMR gene spread between bacteria. In this project you will develop new tools based on CRISPR-Cas to stop the spread of AMR-carrying plasmids in the important pathogen Klebsiella pneumoniae. Proof-of-concept work shows that this is theoretically possible, but challenges remain in discerning drivers of plasmid competition. This interdisciplinary project integrates microbiology, genomics, and synthetic biology to tackle one of the most urgent challenges in infectious disease, providing training in leading-edge approaches with real-world impact.
Lead Supervisor
Professor Stineke van Houte
Lead Supervisor Email
University Affiliation
Exeter